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伍小云

发布时间:2019年10月19日 浏览次数:次


姓    名: 伍小云

职    称: 教授,博士,博士生导师

联系方式: 南方医科大学足球一世66814

Email:  xywu@smu.edu.cn

主要招生方向:药物化学、工业药学


学习经历:

2001.09-2006.07 湖南大学化学化工足球一世66814,硕博连读,博士

1997.09-2001.07 湖南大学化学化工足球一世66814,本科

工作经历:

2019.06- 南方医科大学足球一世66814,教授

2013.12-2019.06 南方医科大学足球一世66814,副教授

2006.12-2013.12 南方医科大学足球一世66814,讲师

研究方向:

计算机辅助的小分子酪氨酸激酶抑制剂的设计、合成及生物活性评价

承担课程:

《药物化学》,《药物设计学》,《计算机辅助药物设计》(研究生课程)

主要科研课题:

1.国家自然科学基金面上基金(81872740),可克服T790M和C797S耐药的EGFR变构抑制剂的设计、合成及生物活性评价,2019.1-2022.12,项目负责人。

2.国家自然科学基金青年基金(81202413),靶向VEGFR-2的II型小分子抑制剂的设计、合成及构效关系研究,2013.1-2015.12,项目负责人,已结题。

主要论著:

1. Wan Shanhe, Yan Ruohong, Jiang Ying, Li Zhonghuang, Zhang Jiajie*, Wu Xiaoyun*. Insight into binding mechanisms of EGFR allosteric inhibitors using molecular dynamics simulations and free energy calculations. J Biomol Struct Dyn, 2019: 37(16):4384-94.

2. Tian Yuanxin, Zhang Ttingting, Long Lifan, Zhonghuang Li, Shanhe Wan, Guangfa Wang, Yonghuan Yu, Ju Hou, Xiaoyun Wu*, Jiajie Zhang*. Design, synthesis, biological evaluation and molecular modeling of novel 2-amino-4-(1-phenylethoxy) pyridine derivatives as potential ROS1 inhibitors. Eur J Med Chem, 2018:143:182-99.

3. Wang Yuanyuan, Wan Shanhe, Li Zhonghuang,Yu Fu, Guangfa Wang, Jiajie Zhang*,Xiaoyun Wu*. Design, synthesis, biological evaluation and molecular modeling of novel 1H -pyrazolo[3,4-d]pyrimidine derivatives as BRAF V600E and VEGFR-2 dual inhibitors. Eur J Med Chem, 2018; 155:210-28.

4. Wu Xiaoyun*, Wang Yuanyuan, Wan Shanhe, Zhang Jiajie*. Investigation on the binding mechanism of loratinib with the c-ros oncogene 1 (ROS1) receptor tyrosine kinase via molecular dynamics simulation and binding free energy calculations. J Biomol Struct Dyn, 2018 ,36(12):3106-13.

5. Wu Xiaoyun*, Fu Yu, Wang Yuanyuan, Wan Shanhe, Zhang Jiajie*. Computational investigation on inhibition mechanism of BRAFV600E by Vemurafenib (PLX4032) and its analogue PLX4720. Med Chem Res, 2017,26(2):390-6.

6. Fu Yu, Wang Yuanyuan, Wan Shanhe, Zhonghuang Li, Guangfa Wang, Jiajie Zhang * and Xiaoyun Wu *. Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies. Molecules, 2017, 22(4):542.

7. Wu Xiaoyun, Fu Yu, Wang Yuanyuan, Wan Shanhe, Zhang Jiajie. Gaining insight into crizotinib resistance mechanisms caused by L2026M and G2032R mutations in ROS1 via molecular dynamics simulations and free-energy calculations. J Mol Model, 2017, 23(4):141-6.

8. Hou Ju , Wan Shanhe , Wang Guangfa, Zhang Tingting, Li Zhonghuang, Tian Yuanxin, Yu Yonghuan, Wu Xiaoyun **, Zhang Jiajie* . Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido[2,3-d]pyrimidine derivatives targeting epidermal growth factor receptor. Eur J Med Chem , 2016,118:276-289.

9. Wu XiaoYun ?, Wan ShanHe, Wang GuangFa, Jin Hong, Li ZhongHuang, Tian YuanXin, Zhu ZhengGuang, Zhang JiaJie ?. Molecular dynamics simulation and free energy calculation studies of kinase inhibitors binding to active and inactive conformations of VEGFR-2. J Mol Graph Model, 2015, 56: 103–112.

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