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陈金香

发布时间:2017年10月17日 浏览次数:次

姓名:陈金香

职称:教授 博士生导师

联系邮箱:jxchen@smu.edu.cn

联系电话:020-61648589

主要招生方向:药物化学、工业药学(药物递送与分析)


学习简历:

1996.09-2000.06 安徽师范大学应用化学专业 获学士学位

2000.09-2003.06 苏州大学无机化学专业 获硕士学位

2003.09-2006.06 苏州大学有机化学专业 获博士学位


工作简历:

2006.07-2009.11 南方医科大学药物化学教研室 讲师

2009.12-2014.11 南方医科大学合成药物化学课题组 副教授

2013.04-2014.04 新加坡科技研究局材料工程研究院 访问学者

2014.12-2015.12 足球一世66814合成药物化学课题组 教授

2016.01-至今 足球一世66814无机药物化学课题组 教授 学科主任

2020年1月-至今 足球一世66814药物分析与化学生物学创新群体 执行主任


研究方向:

1.针对肿瘤微环境构建纳米金属有机骨架复合物用于癌症的精准诊断与治疗

2.基于纳米金属有机骨架材料传输偶联前药对脑部疾病的治疗与追踪

3.具有抗菌活性纳米金属有机骨架复合物的构建及其创面修复功能研究


在研课题:

1.主持国家自然科学基金面上项目,同源细胞膜包裹P-DNA@MOF荧光/MRI双模态探针的构建及其癌症靶向诊断功能研究,项目编号:21874064,项目金额:64万,起止时间:2019年1月-2022年12月。

2.主持广东省自然科学基金项目,具有水稳定性的纳米金属有机骨架的构建及其多种埃博拉病毒核酸分子保守序列同步识别功能研究,项目编号:2018A030313456,项目金额:10万,起止时间:2018年5月-2021年4月。

3.主持广州市科技计划项目,荧光/MRI双模态探针CCMs+P-DNA@MOF的构建及其精准靶向癌症早期诊疗功能研究;项目编号:201904010410,项目金额:20万,起止时间:2019年4月-2022年3月。


5年获得的发明专利:

1.Chen, Jin-Xiang; Xie,Bao-Ping; Qiu, Gui-Hua; Hu, Pei-Pei; Liang, Zhen; Liang, Ye-Mei; Sun, Bin; Bai, Li-Ping; Jiang, Zhi-Hong; Crystalline copper-based coordination polymers and their use. 澳洲发明专利,专利号:AU: 2017100590

2.Chen, Jin-Xiang; Sun, Bin; Xie, Bao-Ping; Jiang,Zhi-Hong; Bai, Li-Ping; Crystalline lanthanum-carboxylate coordination polymers and their use. 澳洲发明专利,AU: 2017100565

3.Chen, Jin-Xiang; Sun, Bin; Zhao, Hai-Qing;Xie, Bao-Ping; Bai, Li-Ping; Jiang, Zhi-Hong; Zwitterionic zinc(II) carboxylate compounds and their use. 澳洲发明专利。专利号:AU: 2016101528

4.Chen, Jin-Xiang; Pang, Jian-Xin; Liu, Shu-Wen;Bai, Li. Ping; Jiang, Zhi-Hong; Crystalline contrast agent for magnetic resonance imaging, kit and composition comprising it and their use. 澳洲发明专利,专利号:AU: 2016101702

5.Chen, Jin-Xiang;Sun, Bin; Zhao, Hai-Qing; Xie,Bao- Ping; Bai, Li-Ping; Jiang, Zhi-Hong; Zwitterionic zinc(II) carboxylate compounds and their use.美国发明专利,专利号:US 10,023,594 B2

6.Chen, Jin-Xiang; Sun, Bin; Xie, Bao-Ping; Jiang,Zhi-Hong; Bai, Li-Ping; Crystalline lanthanum-carboxylate coordination polymers and their use. 美国发明专利,专利号:US 10.260.114 B2。

7.陈金香,杨水平,陈文华,一种两性羧酸镧金属有机骨架及其合成方法和应用,申请号:201510952885.X,授权日:2018年12月4日,专利号:ZL2015 1 0952885.X

8.陈金香,覃亮,陈文华,刘叔文,庞建新,一种基于锰的两性羧酸金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016 1 0404049.2

9.陈金香,覃亮,陈文华,刘叔文,庞建新,一种基于钆的两性羧酸金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 2016 1 0403497.0

10.陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸四核铜金属配位聚合物及其制备方法,专利号:ZL 2016 1 0403491.3

11.陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸双核铜金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 201610404106.7

12.陈金香,覃亮,陈文华,刘叔文,谢宝平,孙斌,一种两性羧酸六核铜金属配位聚合物及其制备方法,中国发明专利,专利号:ZL 201610404108.6


5年以第一作者或通讯作者发表的SCI论文:

1. Ke-Yang Wu#, Ming Chen#, Nai-Hai Huang, Rong-Tian Li, Wei-Lun Pan, Wen-Hua Zhang, Wen-Hua Chen,Jin-Xiang Chen*,Facile and recyclable dopamine sensing by a label-free terbium(III) metal?organic framework, Talanta, 2020, Accepted. (IF=5.339,小类1区,大类2区)

2. Zi-Chuan Yang, Tao-Rui Wang, Rong-Tian Li, Ting-Wei Chen, Yue Fan, Wei-Hua Jiang, Min-Min Li,Jin-Xiang Chen*,Construction of hybrid DNAs@MOF for the rapid synchronous sensing of multiplex microRNAs based on experimental studies and molecular simulation, J. Inorg. Biochem., 2020, 208, 111076. (IF =3.224, 大小类二区)

3. Nai-Han Huang, Yan Liu, Rong-Tian Li, Jing Chen, Pei-Pei Hu, David J. Young,Jin-Xiang Chen,*and Wen-Hua Zhang*, Sequential Ag+/biothiol and synchronous Ag+/Hg2+ biosensing with zwitterionic Cu2+-based metal?organic frameworks, Analyst, 2020, 145, 2779-2788. (IF = 4.019, 大小类2区)

4. Hai-Ling Chen, Rong-Tian Li, Ke-Yang Wu, Pei-Pei Hu, Zhe Zhang, Nai-Han Huang, Wen-Hua Zhang, andJin-Xiang Chen*Experimental and theoretical validations of a one-pot sequential sensing of Hg2+ and biothiols by a 3D Cu-based zwitterionic metal?organic framework, Talanta, 2020, 210, 120596.(IF=5.339,小类1区,大类2区)

5. Rong-Tian Li, Zhen Liang, Meng-Chu Li, Yong Tan, Bao-Ping Xie, Wen-Jun Duan, Chun-Tao Ning,Jin-Xiang Chen*,Bin Sun*, Speedy, Specific, Synchronous Sensing Platforms with Ruthenium Complexes for Multiplexed MicroRNA Detection, Inorg. Chem. 2019, 58, 22, 15126-15137. (IF = 4.85, 小类1区,大类2区)

6. Shi-Xin Lin, Wei-Lun Pan, Ru-Jie Niu, Yan Liu,Jin-Xiang Chen,*Wen-Hua Zhang,* Jian-Ping Lang* and David J. Young, Effective loading of cisplatin into a nanoscale UiO-66 metal–organic framework with preformed defects, Dalton Trans., 2019, 48, 5308–5314. (IF = 4.174, 大小类2区)

7. Shao-Lan Cai, Zi-Chuan Yang, Ke-Yang Wu, Cheng Fan, Ling-Yan Zhai, Nai-Han Huang, Rong-Tian Li, Wen-Jun Duan* andJin-Xiang Chen*,Experimental and computational investigation of a DNA-shielded 3D metal-organic framework for the prompt dual sensing of Ag+ and S2?. RSC adv. 2019, 9, 15424?15430. (IF = 3.119, 大小类3区)

8. Nai-Han Huang, Rong-Tian Li, Cheng Fan, Ke-Yang Wu, Zhe Zhang,Jin-Xiang Chen*Rapid sequential detection of Hg2+ and biothiols by a probe DNA-MOF hybrid sensory system, J. Inorg. Biochem., 2019, 197, 110690. (IF =3.224, 大小类二区)

9. Ke-Yang Wu, Liang Qin, Cheng Fan, Shao-Lan Cai, Bin Sun, Bao-Ping Xie, Xiao-Yan Tang* andJin-Xiang Chen*Sequential and Recyclable Sensing of Fe3+ and Ascorbic Acid Based on a Water-stable Green-emitting Terbium(III) Metal?Organic Framework, Dalton Trans., 2019, 48, 8911-8919. (IF = 4.174, 大小类2区)

10. Bao-Ping Xie, Gui-Hua Qiu, Bin Sun, Zi-Feng Yang, Wen-Hua Zhang,*Jin-Xiang Chen,*Zhi-Hong Jiang* Synchronous sensing of three conserved sequences of Zika virus by a DNAs@MOF hybrid: Experimental and molecular simulation studies, Inorg. Chem. Frontier. 2019, 6, 148-152. (IF = 5.958,小类1区,大类2区)

11. Xiang-Ming Hu, Rong-Tian Li, Miao-Miao Zhang, Ke-Yang Wu, Huan-Huan Li, Nai-Han Huang, Bin Sun*,Jin-Xiang Chen*Phenanthroline-linked berberine dimer and fluorophore-tagged DNA conjugate for the selective detection of microRNA-185: experimental and molecular docking studies, Anal. Chim. Acta, 2019, 1051, 153-159. (IF = 5.977,小类2区,大类2区)

12. Ling-Yan Zhai, Min-Xiang Li, Wei-Lun Pan, Yun Chen, Min-Min Li, Jian-Xin Pang, Lei Zheng*,Jin-Xiang Chen*,Wen-Jun Duan*, In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe, ACS Appl. Mater. Inter. 2018, 10, 39478-39486 (IF 8.758, 大类1区,小类2区)

13. Pei-Pei Hu, Ning Liu, Ke-Yang Wu, Ling-Yan Zhai, Bao-Ping Xie, Bin Sun, Wen-Jun Duan, Wen-Hua Zhang,* andJin-Xiang Chen*Successive and Specific Detection of Hg2+ and I? by a DNA@MOF Biosensor: Experimental and Simulation Studies, Inorg. Chem. 2018, 57(14), 8382-8389. (IF = 4.85, 小类1区, 大类2区)

14. Bao-Ping Xie, Gui-Hua Qiu, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang,Jin-Xiang Chen?Simultaneous detection of Dengue and Zika virus RNA sequences with a three-dimensional Cu-based zwitterionic metal?organic framework, comparison of single and synchronous fluorescence analysis, Sensor. Actuat. B-Chem. 2018, 254C, 1133-1140. (IF 7.1,大小类均1区)

15. Bin Sun, Zhen Liang, Bao-Ping Xie, Rong-Tian Li, Lin-Ze Li, Zhi-Hong Jiang, Li-Ping Bai,Jin-Xiang Chen?,Fluorescence sensing platform based on ruthenium(II) complexes as high 3S (sensitivity, specificity, speed) and “on-off-on” sensors for the miR-185 detection, Talanta, 2018, 179, 658-667.(IF=5.339,小类1区,大类2区)

16. Gui-Hua Qiu, Zi-Hua Weng, Pei-Pei Hu, Wen-Jun Duan, Bao-Ping Xie, Bin Sun, Xiao-Yan Tang?,Jin-Xiang Chen?,Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal–organic framework, Talanta, 2018, 180, 396-402. (IF=5.339,小类1区,大类2区)

17. Liang Qin, Zi-Yan Sun, Kai Cheng, Shu-Wen Liu, Jian-Xin Pang, Li-Ming Xia, Wen-Hua Chen,* Zhen Cheng,* andJin-Xiang Chen*Zwitterionic manganes and gadolinium metal–organic frameworks as efficient magnetic resonance contrast agents for in vivo imaging, ACS Appl. Mater. Inter. 2017, 9(47), 41378-41386. (IF 8.758, 大类1区,小类2区)

18. Shui-Ping Yang, Wei Zhao, Pei-Pei Hu, Ke-Yang Wu, Zhi-Hong Jiang, Li-Ping Bai, Min-Min Li, andJin-Xiang Chen*,Lanthanum-based metal?organic frameworks for specific detection of Sudan virus RNA conservative sequences down to single-base mismatch, Inorg. Chem. 2017, 56, 14880-14887. (IF = 4.85, 小类1区, 大类2区)

19. Gui-Hua Qiua,1 Wan-Zhen Lu1, Pei-Pei Hu, Zhi-Hong Jiang, Li-Ping Bai, Tao-Rui Wang, Min-Min Li, *Jin-Xiang Chen,*A metal-organic framework based PCR-free biosensor for the detection of gastric cancer associated microRNAs, J. Inorg. Biochem. 2017, 177, 138-142. (IF =3.224, 大小类二区)

20. Bin Sun, Hai-Qing Zhao, Bao-Ping Xie, Li-Ping Bai, Zhi-Hong Jiang,Jin-Xiang Chen,*Sequence-specific fluorometric recognition of HIV-1 ds-DNA by using zwitterionic zinc(II)-carboxylate polymers, J. Inorg. Biochem. 2017, 176, 17-23. (IF = 3.348, IF =3.224, 大小类二区))

21. Hai-Qing Zhao, Gui-Hua Qiu, Zhen Liang, Min-Min Li, Bin Sun, Liang Qin, Shui-Ping Yang, Wen-Hua Chen,Jin-Xiang Chen, A Zinc(II)-based two-dimensional MOF for sensitive and selective sensing of HIV-1 ds-DNA sequences, Anal. Chim. Acta, 2016, 922, 55-63. (IF = 5.977,分析化学小类2区,大类2区)

22. Hai-Qing Zhao, Shui-Ping Yang, Ni-Ni Ding, Liang Qin, Gui-Hua Qiu,Jin-Xiang Chen,*Wen-Hua Zhang,* Wen-Hua Chen* and T. S. Andy Hor* A zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: a highly selective sensing platform for HIV ds-DNA sequences, Dalton Trans., 2016, 45, 5092–5100. (IF = 4.029,大小类均2区)

23. Liang Qin, Li-Xian Lin, Zhi-Ping Fang, Shui-Ping Yang, Gui-Hua Qiu,Jin-Xiang Chen*and Wen-Hua Chen* A water-stable metal-organic framework of a zwitterionic carboxylate with dysprosium: a sensing platform for Ebolavirus RNA sequences, Chem. Commu. 2016, 52, 132-135. (IF = 6.164, 大类1区,小类2区)

24. Shui-Ping Yang, Shao-Rui Chen, Shu-Wen Liu, Xiao-Yan Tang, Liang Qin, Gui-Hua Qiu,Jin-Xiang Chen,*Wen-Hua Chen,* Platforms formed from a 3D Cu-based zwitterionic metal?organic framework and probe ss-DNA: selective fluorescent biosensors for HIV-1 ds-DNA and Sudan virus RNA sequences, Anal. Chem. 2015, 87, 12206-12214. (IF = 6.785, ISSN:0003-2700,大小类1区)

25. Ming Chen, Xiao-Yan Tang, Shui-Ping Yang, Huan-Huan Li, Hai-Qing Zhao, Zhi-Hong Jiang,Jin-Xiang Chen,*Wen-Hua Chen,* Five water-soluble zwitterionic copper(II)-carboxylate polymers: role of dipyridyl coligands in enhancing the DNA-binding, cleaving and anticancer activities, Dalton Trans. 2015, 44, 13369-13377. (IF = 4.052,大小类均2区)

26. Ming Chen, Xiao-Yan Tang, Ming-Zhen Chen,Jin-Xiang Chen*,Wen-Hua Chen*, Lanthanide based Polymers with Charged Ligand Backbones: Triple-stranded Chain Structures and their DNA Cleavage Studies, Aust. J Chem. 2015, 48, 493-499. (IF = 1.558, 化学综合三区)

27. Zi-Xuan Zhang, Ni-Ni Ding, Wen-Hua Zhang*,Chen, Jin-Xiang*,Young, David J.*, Andy Hor, T. S.* Stitching 2D Polymeric Layers into Flexible Interpenetrated Metal–Organic Frameworks within Single Crystals, Angew. Chem. Int. Ed. 2014, 53, 4628-4632. (IF = 12.959,大小类均1区)

28.Jin-Xiang Chen,* Ming Chen, Ni-Ni Ding, Wen-Hua Chen, Wen-Hua Zhang,* Andy Hor, T. S.*; Young, David J. * Transmetalation of a Dodecahedral Na9 Aggregate-based Polymer: a Facile Route to Water Stable Cu(II) Coordination Networks, Inorg. Chem. 2014, 53, 7446-7545. (IF = 4.85, 大类2区,小类1区)

29.Jin-Xiang Chen*,Hai-Qing Zhao, Huan-Huan Li, Sheng-Li Huang, Ni-Ni Ding, Wen-Hua Chen, Young, David J.; Wen-Hua Zhang*, Andy Hor, T. S*. Bent Tritopic Carboxylates for Coordination Networks: Clues to the Origin of Self-penetration, CrystEngComm. 2014, 16, 7722-7730. (IF = 3.382,大类2区,小类3区)

30.Jin-Xiang Chen, Lin, W. E.; Chen, M, Que, F. C.; Tao, L.; Cen, X. L.; Zhou, Y. M.; Chen * W. H. Synthesis and DNA photocleaving activities of ancillary ligand-containing zinc complexes of quaternized carboxylates, Inorg. Chim. Acta, 2014, 409, 195–201. (IF = 2.046,大小类4区)


承担课程:

《药物化学》理论课与实验课,《高等药物化学导论》理论课

足球一世66814 - 搜狗指南