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陈之朋

发布时间:2017年10月17日 浏览次数:次

姓名:陈之朋

职称:副教授、硕士生导师

Email: czpwyq@smu.edu.cn

联系电话:020-62789490

主要招生方向:药物化学、工业药学


工作经历:

2005–2020南方医科大学足球一世66814,讲师

2020-至今 南方医科大学足球一世66814,副教授


学习经历:

2000.9–2005.7中山大学,有机化学,硕博连读

1996.9–2000.7曲阜师范大学,化学教育,学士


承担课程:

药物化学,高等有机化学


研究方向:

肿瘤免疫治疗研究

抗病毒药物研究


科研课题:

1、国家自然科学基金,81973183,2020.1-2023.12,项目负责人。

2、国家自然科学基金,81202544,2013.1~2015.12,项目负责人。

3、广州市科技计划项目,2007J1-C0251,2007.1~2009.12,项目负责人。

3、广东省医学科研基金,B2006091,2006.1~2007.12,项目负责人。


发表论文

1.Zhipeng Chen, Xiaohong Cen, Junjie Yang, Zhiman Lin, Meihuan Liu, Synthesis of urea analogues bearing N-alkyl-N’-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors,Eur J Med Chem, 2019, 169: 42-52.

2.Zhipeng Chen, Xiaohong Cen, Junjie Yang, Xiaoshan Tang, Kai Cui, Kui Cheng. Structure-based discovery of a specific TLR1–TLR2 small molecule agonist from the ZINC drug library database.Chem Commun, 2018, 54, 11411-11414.

3.Zhipeng Chen, HaiBo Wang, YuQin Wang, QiuHua Zhu, Yang Xie , ShuWen Liu. Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction.Tetrahedron, 2014, 70: 4379-4385.

4. Suiyi Tan, Jinqing Li, Hongyan Cheng, Zhaofeng Li, Yan Lan, Tingting Zhagn, Zichao Yang, Wenjuan Li, Tao Qi, Yurong Qiu,Zhipeng Chen, Lin Li, Shuwen Liu. The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1.J Biol Chem, 2019, 294(37): 13740-13754.

5. Yao Xu, Shujun Chen, Ying Cao, Pingzheng Zhou,Zhipeng Chen, Kui Cheng. Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents.Eur J Med Chem,2018,154, 253-266.

6. Sichao Zheng, Shufang Zhong,Zhipeng Chen, Wenhua Chen, Qiuhua Zhu. Efficient synthesis of a series of novel octahydroquinazoline-5-ones via a simple on-water urea-catalyzed chemoselective five-component reaction,ACS Comb Sci, 2016, 18, 475-481.

7. Qiuhua Zhu, Lan Huang,Zhipeng Chen, Sichao Zheng, Longyun Lv, Zhibo Zhu, Derong Cao, Huanfeng Jiang, Shuwen Liu, A New Series of C-6 Unsubstituted Tetrahydropyrimidines: Convenient One-Pot Chemoselective Synthesis, Aggregation-Induced and Size-Independent Emission Characteristics,Chemistry-A European Journal,2013, 19(4): 1268-1280.

8. Qiuhua Zhu, Lixin Gao,Zhipeng Chen, Sichao Zheng, Huafei Shu, Jia Li, Huanfeng Jiang, Shuwen Liu, A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions,Eur J Med Chem, 2012, 54: 232-238.

9. Zhibo Zhu, Runming Li, Gaokeng Xiao,Zhipeng Chen, Jie Yang, Qiuhua Zhu, Shuwen Liu, Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion,Eur J Med Chem, 2012, 57: 211-216.

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