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周春琼

发布时间:2017年10月17日 浏览次数:次

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职称:副教授 硕士研究生导师

联系邮箱:zcqlg@smu.edu.cn

联系电话:020-61648549

主要招生方向:药物化学、工业药学


学习简历:

1996.09-2000.06 三峡大学化学教育专业 获学士学位

2000.09-2003.06 山西大学无机化学专业 获硕士学位

2003.09-2006.06 华南理工大学化学工程专业 获博士学位


工作简历:

2006.07-2014.12 南方医科大学足球一世66814 讲师

2015.03-2016.03 英国帝国理工足球一世66814化学系 访问学者

2015.01-至今 南方医科大学足球一世66814 副教授


研究方向:

1. 以G-四链体核酸为靶点的抗肿瘤药物的设计研究

2. 以G-四链体核酸为靶点的抗病毒药物的设计研究

3. AIE荧光染料的设计及肿瘤的光热-化疗联合治疗研究


主要科研课题:

1. 广东省科技计划项目,叶酸偶联G-四链体结合剂及探针靶向癌细胞的生物活性研究,项目编号:2017A050501018,项目经费:50万元,起止时间:2017.09-2021.02,主持。

2.南方医科大学“一带一路”培育项目,双喹啉二聚体化合物的设计及靶向人端粒双倍体G-四链体DNA的生物活性研究,项目编号:YD2017N001,项目经费:6万元,起止时间:2017.10-2019.10,主持。

3. 国家自然科学基金青年基金,选择性识别人端粒双倍体G-四链体的双平面链状分子的合成及调控生物活性研究,项目编号:21402085,项目经费:25万元,起止时间:2015.01-2017.12,主持。

4.广东省科技计划项目,稳定和识别人端粒双倍体G4-DNA的抗肿瘤药物的设计及活性研究,项目编号:2014A050503042,项目经费:50万元,起止时间:2015.08-2017.08,主持。

5.广东省科技计划项目,特异性识别和定位切割人端粒DNA的金属核酸酶技术的联合研究,项目编号:2012B050100007,项目经费:30万元,起止时间:2012.12-2015.11,主持。

6. 南方医科大学科研启动计划,以端粒DNA为靶点的抗肝癌药物的设计, 3W,起止时间:2012.11-2014.10,主持。

7. 绿色催化四川省高校重点实验室开放课题,特异性识别和定位切割DNA的人工核酸酶的构筑,项目编号:LYJ11010,项目经费:1.5万元,起止时间:2011.12-2013.12,主持。

8. 广东省自然科学基金,人工酶与肝靶向载体乳糖化壳聚糖偶联物的抗肝癌研究,项目编号:7300452,项目经费:3万元,起止时间:2007.10-2009.12,主持。


以第一作者或通讯作者发表的SCI论文:

1. M. Zou#, J.-Y. Li#, M.-J. Zhang#, J.-H. Li, J.-T. Huang, P.-D. You, S.-W. Liu*, C.-Q. Zhou*, G-quadruplex binder pyridostatin as an effective multi-target ZIKV inhibitor, Int. J. Bio. Macromol., 2021, 190, 178-188.

2. J.-H. Li, T.-Z. Ma, J.-L. Fu, J.-T. Huang, M.-J. Zhang, P.-D. You, C.-Q. Zhou*, Bisquinolinium-fluorescein conjugates as specific fluorescence probes of c-myc Pu22 G-quadruplexe and their bioimaging and anticancer activities, Dyes and Pigments, 2021, 190, 109304.

3. T.-C. Liao, T.-Z. Ma, S.-B. Chen, A. Cilibrizzi, M.-J. Zhang, J.-H. Li, C.-Q. Zhou*, Human telomere double G-quadruplex recognition by berberine-bisquinolinium imaging conjugates in vitro and in cells, Int. J. Bio. Macromol., 2020, 158, 1299-1309.

4. T.-Z. Ma, M.-J. Zhang, T.-C. Liao, J.-H. Li, M. Zou, Z.-M. Wang, C.-Q. Zhou*, Dimers formed with the mixed-type G-quadruplex binder pyridostatin specifically recognize human telomere G-quadruplex dimers, Org. Biomol. Chem., 2020, 18, 920-930.

5. T.-C. Liao, T.-Z. Ma, Z. Liang, X.-T. Zhang, C.-Y. Luo, L. Liu, C.-Q. Zhou*, A comparative study on high selectivities of human telomeric dimeric G-quadruplexes by dimeric G-quadruplex binders, Chem. Eur. J., 2018, 24, 15840-15851.

6. C.-Q. Zhou*, Z.-Q. Li, T.-C. Liao, T.-Z. Ma, S.-B. Chen, Y.-Y. Liang, A novel square-planar Pt(II) complex as a monomeric and dimeric G-quadruplex DNA binder, RSC Adv., 2018, 8, 23257-23261.

7. Z.-Q. Li, T.-Q. Liao, C. Dong, J.-W. Yang, X.-J. Chen, L. Liu, Y. Luo, Y.-Y. Liang, W.-H. Chen*, C. -Q. Zhou*, Specifically targeting mixed-type dimeric G-quadruplexes using berberine dimmers, Org. Biomol. Chem., 2017, 15, 10221-10229.

8. C.-Q. Zhou, T.-C. Liao, Z.-Q. Li, J. Gonzalez-Garcia, M. Reynolds, M. Zou, R. Vilar*, Dinickel-salphen complexes as binders of human telomeric dimeric G-quadruplexes, Chem. Eur. J., 2017, 23, 4713-4722.

9. C.-Q. Zhou, J.-W. Yang, C. Dong, Y.-M. Wang, B. Sun, J.-X. Chen, Y.-S. Xu, W.-H. Chen *, Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine, Org. Biomol. Chem., 2016, 14: 191-197.

10. C. Dong, C.-Q. Zhou *, J.-W. Yang, T.-C. Liao, J.-X. Chen, C.-X. Yin, W.-H. Chen *, A novel 3, 6-diamino-1, 8-naphthalimide derivative as a highly selective fluorescent “turn-on” probe for thiols, RSC. Adv., 2015, 5: 32990-32993.

11. C.-Q. Zhou, J.-W. Yang, C. Dong, Y.-L. Lin, J. X. Chen, W.-H. Chen *, Synthesis, DNA-cleaving activities and cytotoxicities of the copper(II) complexes of pyrrole-polyamide dimmers tethered with carboxylate-containing linkers, Inorg. Chim. Acta. 2015, 429: 168-173.

12. J.-W. Yang, Y.-L. Lin, C. Dong, C.-Q. Zhou *, J.-X. Chen, B. Wang, Z.-Z. Zhou, B. Sun, W.-H. Chen *, Synthesis, hydrolytic DNA-cleaving activities and cytotoxicities of EDTA analogue-tethered pyrrole-polyamide dimer-based Ce(IV) complexes, Eur. J. Med. Chem. 2014, 87: 168-174.

13. C.-Q. Zhou, Y.-L. Lin, J.-W. Yang, J.-X. Chen, W.-H. Chen*, Synthesis, DNA-cleaving and cytotoxicities of C2-symmetrical dipyrrole-polyamide dimer-based Cu(II) complexes: A comparative study, Eur. J. Med. Chem. 2013, 66: 508-515.

14. Y.-M. Wang #, C.-Q. Zhou #, Y.-L. Lin, J.-X. Chen, B.-C. Kuang, W.-L. Fu, W.-H. Chen*, Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(II) ion, Med. Chem. Comm. 2013, 4: 1400-1404.

15. C.-Q. Zhou, Y.-L. Lin, J.-X. Chen, L.-S. Wang, N.-N. Yang, W. Zeng, W.-H. Chen*, Facile synthesis of a dimeric pipyrrole-polyamide and synergetic DNA-cleaving activity of its Cu(II) complex, Bioorg. Med. Chem. Lett. 2012, 22: 5853-5856.

16. C.-Q. Zhou, Y.-L. Lin, J.-X. Chen, W.-H. Chen*, Synergetic DNA-cleaving activities of metal complexes of a polyether-tethered pyrrole-polyamide dimer, Chem. Biodiv. 2012, 9: 1125-1132.

17. M. Zou, S.-W. Liu, C.-Q. Zhou*, Synthesis and studies on DNA-binding of a new nickel complex with pyrrole and polyamine, Acta. Chim. Sinica. 2010, 68(6): 481-486.

18. C.-Q. Zhou, M. Zou, W.-W. You, Z.-K. Tang, R.-F. Guo, Synthesis, DNA-binding and cleavage studies by cobalt complex of pyrrole-multiamine, Chin. J. Inorg. Chem. 2010, 26(2): 257-262.


发明专利:

1.周春琼,廖廷聪,马天著,一种小檗碱-Pyridostatin偶联物及其制备方法和应用,2019.04,中国发明专利,授权专利号:ZL 201910315073.2。

2.周春琼,廖廷聪,一种双喹啉二聚体衍生物及其制备方法和应用,2018.01,中国发明专利,授权专利号:ZL 20181007300.0。

3.周春琼,陈文华,杨建伟,董承,一种免标记荧光探针及其在检测双倍体G-四链体结构中的应用,2015.09,中国发明专利,授权专利号:ZL201510591175.9。

4.周春琼,周中振,一种对称的多胺与吡咯聚酰胺缀合物及其制备方法,2011.09,中国发明专利,授权专利号:ZL200910194140.6。

5.周春琼,廖廷聪,马天著,一种小檗碱-360A偶联物及其制备方法和应用,2019.04,中国发明专利,申请号:ZL 2019103144449.8。

6.邹敏,柳红妙,姚新刚,周春琼,柯昌文,杨海涛,刘叔文,槲皮素及其衍生物在制备康寨卡病毒药物中的应用,2019.01,中国发明专利,申请号:ZL 201910047562.1。

7.邹敏,柳红妙,姚新刚,周春琼,柯昌文,杨海涛,刘叔文,表没食子儿茶及其衍生物在制备康寨卡病毒药物中的应用,2019.01,中国发明专利,申请号:ZL 201910047562.1。


承担课程:

《物理化学》

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