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陈俊

发布时间:2020年08月28日 浏览次数:次

姓名:陈俊

单位:足球一世66814

职称:副教授(六级岗),硕士生导师

邮箱:chenj258@smu.edu.cn

主要招生方向:药物分析学、工业药学


学习经历:

2014.08-2019.06 中山大学,分析化学,博士(硕博连读)

2010.09-2014.06 桂林理工大学,应用化学,本科


工作经历:

2019.07-至今南方医科大学足球一世66814,副教授


研究方向:

药物分析(DNA纳米技术、生化分析及生物传感、细胞成像)


主要科研课题:

1.南方医科大学高层次人才引进科研启动项目,活细胞亚细胞器内疾病标志物microRNA的原位分析(2019.09-2022.09)

2.国家自然科学基金青年基金(2021.01-2023.12)

3. 广州市基础研究计划项目(2021.04-2023.04)


代表性成果:

1. Chen Jun, Zhou Xueqing, Ma Yingjun, Lin, Xiulian, Dai Zong* and Zou Xiaoyong, Asymmetric exponential amplification reaction on a toehold/biotin featured template: an ultrasensitive and specific strategy for isothermal microRNAs analysis. Nucleic Acids Res., 2016, 44, e130.(IF=16.971)

2. Chen Jun, An Taixue, Ma Yingjun, Situ Bo, Chen Danping, Xu Yuzhi, Zhang Li, Dai Zong* and Zou Xiaoyong, Isothermal amplification on a structure-switchable symmetric toehold dumbbell-template: A strategy enabling microRNA analysis at the single-cell level with ultrahigh specificity and accuracy. Anal. Chem., 2018, 90, 859-865. (IF=6.986)

3. Chen Jun, Yin Wen, Ma Yingjun, Yang Hui-Hui, Zhang Yanfei, Xu Mengfei, Zheng Xuling, Dai Zong* and Zou Xiaoyong, Imaging of intracellular-specific microRNA in tumor cells by symmetric exponential amplification assisted fluorescence in situ hybridization. Chem. Commun., 2018, 54, 13981-13984.(IF=6.222)

4. Chen Jun, Yang Hui-Hui, Yin Wen, Zhang Yanfei, Ma Yingjun, Chen Danping, Xu Yuzhi, Liu Si-Yang, Zhang Li, Dai Zong* and Zou Xiaoyong, Metastable dumbbell probe-based hybridization chain reaction for sensitive and accurate imaging of intracellular-specific microRNAs in situ in living cells. Anal. Chem., 2019, 91, 4625–4631.(IF=6.986)

5. Chen Jun, Zhang Yanfei, Chen Danping, Wang Tianchen, Yin Wen, Yang HuiHui, Xu Yuzhi, Chen Jin-Xiang, Dai Zong* and Zou Xiaoyong, Toehold-mediated ligation-free rolling circle amplification enables sensitive and rapid imaging of messenger RNAs in situ in cells. Anal. Chim. Acta, 2021, 1160, 338463. (IF=6.558)

6. Chen Jun, Zhang Yanfei, Xie Baoping, Sun Bin, Duan Wenjun, Li Minmin, Chen Jin-Xiang*, Dai Zong* and Zou Xiaoyong, A protein triggering exponential amplification reaction enables label- and wash-free one-pot protein assay with high sensitivity. Talanta, 2021, 225, 121980. (IF=6.057)

7. Chen Jun,* Zhu Daozhong, Huang Ting, Yang Zizhong, Liu Birong, Sun Mengxu, Chen Jin-Xiang, Dai Zong,* and Zou Xiaoyong, Isothermal self-primer EXPonential amplification reaction (SPEXPAR) for highly sensitive detection of single-stranded nucleic acids and proteins. Anal. Chem. 2021, 93, 12707?12713(IF=6.986)

8. Huang Ting, Chen Guixun, Liu Birong, Yang Zizhong, Huang Yuanwei, Xie Baoping, Li Min-Min, Chen Jin-Xiang,* Chen Jun,* Dai Zong, An intramolecular DNAzyme-based amplification for miRNA analysis with improving reaction kinetics and high sensitivity. Talanta, 2022, 239, 123137(IF=6.057)

9. Yin Wen, Chen Jun, Yang Huihui, Zhang Yanhui, Dai Zong* and Zou Xiaoyong, Sensitive and sustained imaging of intracellular microRNA in living cells by a high biocompatible liposomal vehicle introduced isothermal symmetric exponential amplification reaction. Chem. Commun., 2019, 55, 11251-11254. (IF=6.222)

10. Ma Yingjun, Chen Jun, Chen Danping, Xu Yuzhi, Zhang Li, Dai Zong* and Zou Xiaoyong, Short-probe-based duplex-specific nuclease signal amplification strategy enables imaging of endogenous microRNAs in living cells with ultrahigh specificity. Talanta, 2018,186, 256-264.(IF=6.057)

11. Li Chunrong, Zhang Yanfei, Chen Jun, Liu Liping, Yang Huihui, Liu Siyang, Xu Yuzhi, Dai Zong* and Zou Xiaoyong*, Fluorescence on-off-on with small and charge-tunable nanoparticles enables highly sensitive intracellular microRNA imaging in living cells, Talanta, 2021, 225, 121980. (IF=6.057)

12. Chen Danping, Wang Yang, Mo Mingming, Zhang Junjie, Zhang Yanfei, Xu Yuzhi, Liu Si-Yang, Chen Jun, Ma Yingjun, Zhang Li, Dai Zong*, Cai Chun and Zou Xiaoyong, Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input. Nucleic Acids Res., 2019, 47, e119.(IF=16.971)

13. Chen Danping, Wang Yang, Chen Jun, Zhang Yanfei, Dai Zong* and Zou Xiaoyong, Polymerization retardation isothermal amplification strategy enables the sensitive and facile investigation of the flanking sequence preference of ten?eleven translocation 2 protein, Anal. Chim. Acta., 2020, 1109: 140-147.(IF=6.558)

14. Zhang Li, Xiao Xiaofen, Xu Yuzhi, Chen Danping, Chen Jun, Ma Yingjun, Dai Zong* and Zou Xiaoyong*, Electrochemical assay for continuous monitoring of dynamic DNA methylation process, Biosens. Bioelectron., 2018, 100, 184-191.(IF=10.618)

15. Zhou Xueqing, Liang Yongqian, Xu Yuzhi, Lin Xiulian, Chen Jun, Ma Yingjun, ZhangLi, Chen Danping, Song Fenyun, Dai Zong* and Zou Xiaoyong*, Triple cascade reactions:An ultrasensitive and specific single tube strategy enabling isothermal analysis ofmicroRNA at sub-attomole level, Biosens. Bioelectron., 2016, 80, 378-384.(IF=10.618)

16. Zhang Li, Xu Yuzhi, Xiao Xiaofen, Chen Jun, Zhou Xueqing, Zhu Wenyuan, DaiZong* and Zou Xiaoyong*, Development of techniques for DNA-methylation analysis. TrAC-trends Anal. Chem., 2015, 72, 114-122.(IF=12.296)

17.戴宗,陈俊,邹小勇,一种改进型恒温指数扩增技术及其在microRNA检测中的应用,国家发明专利,ZL 201510383439.1

18.戴宗,陈俊,邹小勇,一种基于对称环状哑铃模板的核酸恒温指数扩增技术及其在microRNA检测中的应用,国家发明专利,ZL 201610929332.7

29.戴宗,陈俊,邹小勇,一种环状哑铃型探针及其应用,国家发明专利,ZL 201810076030.9

20.戴宗,陈俊,邹小勇,一种基于 DNA 组装的恒温条件下同时检测多种microRNA的探针和方法,国家发明专利,201810819681.2

21.陈俊,夏苏平,谢文清,陈金香,谢宝平,刘叔文,一种适配体及其在检测PDGFBB试剂盒中的应用,国家发明专利,202010173438

22.陈俊,黄婷,刘碧蓉,杨子中,孙蒙旭,陈金香,谢宝平,段文军,基于单个探针的自引物恒温指数扩增方法在检测长链核酸中的应用,国家发明专利,202110376763.6

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