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林汉斌

发布时间:2022年08月31日 浏览次数:次

 

姓名:林汉斌

单位:中国科足球一世66814上海药物研究所/中科中山药物创新研究院

职称:研究员,博士生生导师

联系邮箱:linhanbin@simm.ac.cn

联系电话:13823902683

个人主页:https://www.zidd.ac.cn/headofresearchgroup/info.aspx?itemid=341


学习经历:

2010.9-2014.9  萨斯喀彻温大学医足球一世66814药理学系,药理学博士,师从 Greg Sawicki教授

2007.7-2010.6  北京理工大学, 生命科与技术足球一世66814,师从邓玉林教授

 

工作经历:

2021.3-至今 中国科足球一世66814上海药物研究所/中科中山药物创新研究院,课题组长,博士生导师,四级研究员,科研发展部部长

2014.11-2021.2 渥太华心脏研究所及多伦多大学渥太华心脏研究所,心脏功能科,博士后,师从刘丕教授,从事心脏免疫学研究。


研究方向: 

心血管疾病病理学、心血管疾病药理学、蛋白质组学、代谢组学,中医药现代化,药食同源


主要学术任职:

中科中山药物创新研究院科研发展部部长


主要获奖情况:

2022.08 广东省“珠江人才”青年拔尖

2021.09 2021年度“新时代中山市青年岗位能手”

2017.08 European Society of Cardiology Congress 2017 travel grant for basic science

2017.08 European Society of Cardiology Congress 2017 young investigator award

2017.08 Canadian Institutes of Health Research (CIHR) for an Institute Community Support (ICS) Travel Award with the Institute of Circulatory and Respiratory Health

2017.06 Ottawa Heart Institute Cardiac Research Endowed Fellowship

2014.06 国家优秀自费留学生奖学金


近年主持或参加科研项目:

1.探索免疫蛋白因子在心血管疾病药理和病理机制中的调控作用,科研团队领军人才匹配经费,2021.3—2026.3,1000万

2.抑制MAVS信号通路抗心脏缺血/再灌注损伤的机制研究,国家自然科学基金青年科学基金项目,2022.1.1—2024.12.31,30万

3.常规制剂开发技术服务,企业横向,2021.11-2023.11,17.5万

4.博士后科研经费,中国科足球一世66814,2021.11--2023.11,8万

5.LncRNA-H19Let7aIL6炎症信号通路在动脉粥样硬化发生中的机制研究,2022.7.1-2025.6.30,中山市社会公益科技研究项目,5万

6.阿达木单抗血药浓度监测方法构建及其用于克罗恩病患者个体化给药方案研究,2022.7.1-2025.6.30,中山市社会公益科技研究项目,5万

7.基于蛋白质组学研究益气化瘀方改善急性冠脉综合征PCI术患者临床疗效,2022.7.1-2025.6.30,中山市社会公益科技研究项目,5万

8. 中科中山药物创新研究院特色科普教育基地建设, 2022.9-2025.8 中山市社会公益科技研究项目,10万 

 

代表性论文:

1.Li Feng, Yue Wang, Jian Yang, Yi-fan Sun, Yi-wei Li, Zi-hong Ye, Han-bin Lin, Ke Yang.Overview of the preparation method, structure and function, and application of natural peptides and polypeptides. Biomedicine & Pharmacotherapy,Volume 153,2022,113493.

2.Ke Yang, Yue Wang, Yi-wei Li, Yi-gong Chen, Na Xing, Han-bin Lin, Ping Zhou, Xiao-ping Yu,Progress in the treatment of diabetic peripheral neuropathy, Biomedicine & Pharmacotherapy,Volume 148, 2022, 112717.

3.Yang ke, Huang Jian-yuan, Zhou ping, Wang yue, Xing Na, Yang Jian, Lin Kai-xuan, Sun Yi-fan, Han-Bin Lin, Li Rong. The progressive application of single cell RNA sequencing technology in cardiovascular diseases. Biomedicine & Pharmacotherapy,2022,(In Press).

4.Han-Bin Lin, PhD and Peter P. Liu, MD. (2020). COVID-19 and the Heart, ACE2 Level and the Company it Keeps Hold the Key. JACC: Basic to Translational Science. 5(9): 884-887.

5.Han-Bin Lin, Kotaro Naito, Yena Oh, Gedaliah Farber; Georges Kanaan, Alan Valaperti, Fayez Dawood, Liyong Zhang,Guo Hua Li, David Smyth, Mark Moon, Youan Liu, Wenbin Liang,Benjamin Rotstein,Dana Philpott, Kyoung-Han Kim, Mary-Ellen Harper,Peter P Liu, (2020). Innate immune Nod1/RIP2 signaling is essential for cardiac hypertrophy, - but requires mitochondrial antiviral signaling protein (MAVS) for signal transductions and energy balance.

6. Michael A. J. Moser, Steve Arcand, Han-Bin Lin, Chris Wojnarowicz, Jolanta Sawicka Tamalina Banerjee, Yigang Luo, Gavin R. Beck, Patrick P. Luke, and Grzegorz Sawicki. (2016). Protection of the Transplant Kidney from Preservation Injury by Inhibition of Matrix Metalloproteinases.PLoS One. 11(6): 0-0.

7. Iwona Bil-Lula, Han-Bin Lin, Dariusz Biay, Magdalena Wawrzyska, Lucas Diebel, Jolanta Sawicka, Mieczyslaw Wo?niak, Grzegorz Sawicki. (2016). Subthreshold nitric oxide synthase inhibition improves synergistic effects of subthreshold MMP-2/MLCK-mediated cardiomyocyte protection from hypoxic injury. Journal of Cellular and Molecular Medicine. 20(6): 1086–1094.

8. Han-Bin Lin, Virgilio J. J. Cadete, Bikramjit Sra, Jolanta Sawicka, Zhicheng Chen, Lane K. Bekar, Francisco Cayabyab, Grzegorz Sawicki. (2014). Inhibition of MMP-2 expression with siRNA increases baseline cardiomyocyte contractility and protects against simulated ischemic reperfusion injury. BioMed Research International. 2014: 11.

9. Han-Bin Lin, Keshav Sharma, Dariusz Bialy, Magdalena Wawrzynska, Randy Purves, Francisco Cayabyab, Mieczyslaw Wozniak, Grzegorz Sawicki. (2014). Inhibition of MMP-2 expression affects the levels of metabolic enzymes: Proteomic analysis of rat cardiomyocytes. Journal of Proteomics. 106(25): 74-85.

10. Virgilio J. J. Cadete, Steven Arcand, Han-Bin Lin, Grzegorz Sawicki. (2013). Synergy in protection against cardiac ischemia/reperfusion injury: a novel therapeutic paradigm for the future. Future Medicinal Chemistry. 5(4): 389-398.

11. Lin Han-Bin*,Cadete Virgilio JJ*, Sawicka Jolanta, Wozniak Mieczyslaw, Sawicki Grzegorz. (2012). Proteomic analysis of right and left cardiac ventricles under aerobic conditions and after ischemia/ reperfusion.Proteomics. 12(14): 2366-2377.

12. Lin Han-Bin, Cadete Virgilio JJ, Sawicka Jolanta, Wozniak Mieczyslaw, Sawicki Grzegorz. (2012). Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia/reperfusion injury. Journal of Proteomics. 75(17): 5386-5395.


发明专利:

一种医药试剂加工的具有高精度筛选功能的提炼框(ZL202010465646.2)


教材或专著:

染色体17q12微缺失


指导学生获奖:

指导傅丽丹同学获得遵义医科大学优秀本科毕业论文

指导南方医科大学陈梓琪同学获得中科中山药物创新研究院优秀实习生评选活动三等奖

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