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任益昌

发布时间:2018年09月13日 浏览次数:次

 

姓名:任益昌

职称: 实验师

联系邮箱:r1535181026@smu.edu.cn

 

学习经历:

2011.9-2015.6 广东药科大学,药学,学士

2015.9-2018.6 暨南大学,药物化学,硕士

 

工作经历:

2018.7- 南方医科大学足球一世66814,科研助理

 

论文发表

1. Ren, Y. #; Wang, Y. #; Li, G #.; Zhang, Z.; Ma, L.; Cheng, B.; Chen, J. Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities. J Med Chem 2021, 64, 4498-4515.

2. Komuraiah, B#.; Ren, Y. #; Xue, M.; Cheng, B.; Liu, J.; Liu, Y.; Chen, J. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities. Chem Biol Drug Des 2021, 97, 1109-1116.

3. Deng, X.; Mai, R.; Zhang, C.; Yu, D.; Ren, Y.; Li, G.; Cheng, B.; Li, L.; Yu, Z.; Chen, J.* Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment. Eur J Med Chem 2020, 113050.

4. Cheng, B.; Wang, W.; Niu, X.; Ren, Y.; Liu, T.; Cao, H.; Wang, S.; Tu, Y.; Chen, J.; Liu, S.; Yang, X.; Chen, J.* Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment. J Med Chem 2020, 63, 15946-15959.

5. Li, G.; Wang, Y.; Li, L.; Ren, Y.; Deng, X.; Liu, J.; Wang, W.; Luo, M.; Liu, S.; Chen, J.* Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem 2020, 202, 112519.

6. Peng, X.; Li, L.; Ren, Y.; Xue, H.; Liu, J.; Wen, S.; Chen, J.* Synthesis of N-Carbonyl Acridanes as Highly Potent Inhibitors of Tubulin Polymerization via One-Pot Copper-Catalyzed Dual Arylation of Nitriles with Cyclic Diphenyl Iodoniums. Advanced Synthesis & Catalysis 2020, 362, 2030-2038.

7. Cheng, B.; Ren, Y.; Niu, X.; Wang, W.; Wang, S.; Tu, Y.; Liu, S.; Wang, J.; Yang, D.; Liao, G.; Chen, J.* Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction as Potential Anticancer Agents. J Med Chem 2020, 63, 8338-8358.

8. Cheng, B.; Ren, Y.; Cao, H.; Chen, J.* Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem 2020, 199, 112377.

9. Li, X.; Ren, Y.; Bao, Y.; Liu, J.; Zhang, X.; Zhang, Y.; Sun, X.; Yao, X.*; Tang, J.* Synthesis of C3-Neoglycosides of digoxigenin and their anticancer activities. Eur J Med Chem 2018, 145, 252-262.

10. Geng, X. #; Ren, Y. #; Wang, F.; Tian, D.; Yao, X.; Zhang, Y. *; Tang, J.* Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy. Biochem Biophys Res Commun 2018, 498, 99-104.


专利

1.陈建军,邓欣,麦瑞堯,任益昌,程斌斌。一种多肽-紫杉醇偶联物及其应用,2020.06.02,中国,202010488241.0

2.陈建军,程斌斌,任益昌。一种泊马度胺衍生物及其用途,2020.04.07,中国,202010262495.0

3.陈建军,彭孝鹏,李玲,任益昌,刘进。一种N-羰基-9,10-二氢吖啶类化合物及其应用,2019.11.12,中国,201911098382.5

4.陈建军,李刚,邓欣,任益昌,李玲。一种7-(三甲氧基苯基)-吡咯并[2,3-d]嘧啶及其应用,2019.09.04,中国,201910830613.0

5.陈建军,任益昌,程斌斌。一种苯并五元氮杂环衍生物及其应用,2019.08.30, 中国,201910812479.1

6.陈建军,李刚,邓欣,任益昌。一种2-(吲哚-3-基)-吡啶并咪唑及其应用,2019.02.25, 中国,201910135974.3



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