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陈景考

发布时间:2018年03月19日 浏览次数:次


姓名: 陈景考

职称:副教授

联系邮箱:50155384@qq.com

联系电话:020-61648196

主要招生方向:药理学、工业药学 


学习经历:

2003.092007.06,中山大学,生物技术,学士

2007.09 – 2012.06,中山大学,药理学,博士

2012.7-2015.8,广州医科大学,附属第二医院神经科学研究所,博士后


工作经历:

2015/10-2017.12,中山大学足球一世66814,特聘副研究员

2018.1-南方医科大学足球一世66814,讲师


研究方向:

肿瘤治疗新策略


主要科研课题:

1. 国自然青年基金,81703539,靶向组蛋白去乙酰化酶和SGK1的新型大黄酸衍生物SYSUP007多靶点抗胶质瘤作用研究,2018.01-2020.12。

2. 广东省脑功能与脑疾病重点实验室开放课题基金,2016A2, AGEs/RAGE/Rho/ROCK通路在AD非特异性炎症中的作用及机制, 2016.09-2017.09。

3. 博士后科学基金,2013M542162,姜黄素通过TRPM7抑制恶性胶质瘤细胞增殖, 2013/09 - 2015/09。

4. 广州医科大学博士启动项目,2012C48,抑郁症的表观遗传学研究,2012/12 - 2014/12。


代表性论文:

(1) Chen J, Yin W, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R(*): L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-kappaB inhibition and Nrf2 pathway activation. Eur J Pharmacol 2017, 806:1-9.

(2) Chen J, Sun Z, Jin M, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R(*): Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-kappaB pathway. J Neuroimmunol 2017, 305:108-114.

(3) Luo L(#), Chen J(#), Su D(#), Chen M, Luo B, Pi R, Wang L, Shen W, Wang R(*).L-F001, a Multifunction ROCK Inhibitor Prevents 6-OHDA Induced Cell Death Through Activating Akt/GSK-3beta and Nrf2/HO-1 Signaling Pathway in PC12 Cells and Attenuates MPTP-Induced Dopamine Neuron Toxicity in Mice. Neurochem Res: 2017; 42:615-624.

(4) Chen J, Dou Y, Zheng X, Leng T, Lu X, Ouyang Y, Sun H, Xing F, Mai J, Gu J, Lu B, Yan G, Lin J(*), Zhu W(*): Trpm7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma. Tumour biology : 2016;37:14721-14731.

(5) Chen J,Ouyang, Ying,Cao, Lin,Zhu, Wenbo,Zhou, Yuxi,Zhou, Yuehan,Zhang, Haipeng,Yang, Xiaoxiao,Mao, Lifang,Lin, Suizhen,Lin, Jun(*) ,Hu, Jun(*),Yan, Guangmei,Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest.,J Neurosurg Anesthesiol,2013,253):285-291。

(6) Wang SN, Li Q, Jing MH, Alba E, Yang XH, Sabate R, Han YF, Pi RB, Lan WJ, Yang XB, Chen J*. Natural xanthones from garcinia mangostana with multifunctional activities for the therapy of alzheimer's disease. Neurochemical research 2016;41:1806-1817.

(7) Chen Q-H, Pi R-B, Chen J*. Pharmacology of rhein and advancement in the synthesis of its derivatives. Current Traditional Medicine 2016;2:59-69

(8) 陈秋荷, 皮荣标, 和陈景考*, 大黄酸及其衍生物:合成与药理作用研究进展. 药学研究, 2016. 35(3): p. 161-167.

(9) Li K, Tu Y, Liu Q, Ouyang Y, He M, Luo M, Chen J, Pi R, Liu A: PT93, a novel caffeic acid amide derivative, suppresses glioblastoma cells migration, proliferation and MMP-2/-9 expression. Oncol Lett 2017, 13:1990-1996

(10) Chen, Z. W., Liu, A., Liu, Q., Chen J., Li, W. M., & Chao, X. J., et al. Mef2d mediates the neuroprotective effect of methylene blue against glutamate-induced oxidative damage in ht22 hippocampal cells. Molecular Neurobiology, 2016. 1-14.

(11) Chen Z, Digiacomo M, Tu Y, Gu Q, Wang S, Yang X, Chu J, Chen Q, Han Y, Chen J, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for alzheimer's disease. European journal of medicinal chemistry 2016. 125:784-792.

(12) Tu, Y., Chen, Q., Wang, S., Uri, A., Yang, X., & Chu, J. Chen J., et al. Discovery of lipoic acid-4-phenyl-1h-pyrazole hybrids as novel bifunctional rock inhibitors with antioxidant activity. Rsc Advances.2016 6.(63)

(13) Gao, X. Y., Wang, S. N., Yang, X. H., Lan, W. J., Chen, Z. W., &Chen J., et al. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochemical Research, 2016:1-11.

(14) Chu, Jiaqi,Tu, Yalin,Chen J.,Tan, Dunxian,Liu, Xingguo,Pi, Rongbiao(*),Effects of melatonin and its analogues on neural stem cells,Molecular & Cellular Endocrinology,2016,420:169-79。

(15) He, Mingliang,Luo, Ming,Liu, Qingyu,Chen J,Li, Kaishu,Zheng, Meiguang,Weng, Yinlun,Liu, Anmin(*),Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy,J Neurooncol,2016,pp1-10。

(16) Hu, Haiyan,Zhou, Yuehan,Leng, Tiandong,Liu, Ailing,Wang, Youqiong,You, Xiuhua,Chen J,Tang, Lipeng,Chen, Wenli,Qiu, Pengxin,Yin, Wei,Huang, Yijun,Zhang, Jingxia,Wang, Liwei,Sang, Hanfei,Yan, Guangmei(*),The major cholesterol metabolite cholestane-3beta,5alpha,6beta-triol functions as an endogenous neuroprotectant.,Journal of Neuroscience,2014,3434):11426-11438。

(17) Dou, Yunling,Li, Yuan,Chen J,Wu, Sihan,Xiao, Xiao,Xie, Shanshan,Tang, Lipeng,Yan, Min,Wang, Youqiong,Lin, Jun,Zhu, Wenbo,Yan, Guangmei,Inhibition of cancer cell proliferation by midazolam by targeting transient receptor potential melastatin 7.,Oncology Letters,2013,53):1010-1016。

(18) Yang, Xiaoxiao,Li, Shifeng,Li, Wande,Chen J,Xiao, Xiao,Wang, Youqiong,Yan, Guangmei,Chen, Lijun(*),Inactivation of lysyl oxidase by beta-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells.,Oncology Reports,2013,292):541-548。

(19) Zhang, H ,Zhu, W,Su, X,Wu, S,Lin, Y,Li, J,Wang, Y,Chen J,Zhou, Y,Qiu, P,Yan, G,Zhao, S,Hu, J,Zhang, J,Triptolide inhibits proliferation and invasion of malignant glioma cells.,Journal of Neuro-Oncology,2012,1091):53-62。

(20) Shu, Minfeng,Zhou, Yuehan,Zhu, Wenbo,Zhang, Haipeng,Wu, Sihan,Chen J,Yan, Guangmei(*),MicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathway.,Molecular Pharmacology,2012,813):292-298。


发明专利:

1. 皮荣标, 涂亚林,文石军,王胜男,杨晓红,陈秋荷,陈景考。治疗中枢神经系统退行性疾病或脑肿瘤的化合物及其应用,中国国家发明专利申请号:201610667749.0

2. 皮荣标,颜金武,杨晓红,陈紫薇,王胜男,陈景考。咔唑-利凡斯的明二聚体及其药物组合物和应用,中国国家发明专利申请号:201610385701.0

3. 皮荣标,涂亚林,文石军,王胜男,杨晓红,陈秋荷,陈景考。治疗中枢神经系统退行性疾病的化合物及其应用。中国国家发明专利申请号:201610304191.X

4. 皮荣标;张晓;涂亚林;王胜男;杨晓红;陈秋荷;陈景考。 8-氨基喹啉-羟基咔唑杂联体,其制备方法及其药物组合物。中国国家发明专利申请号:20161103424241.3

 

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